منابع مشابه
Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity
Alzheimer's disease (AD) is known to be caused by the accumulation of amyloid-β peptide (Aβ). The accumulation of Aβ has been shown to cause learning and memory impairment in rats, and it has been shown that hydrogen sulfide donors, such as sodium hydrosulfide (NaHS) can attenuate these effects. However, the underlying mechanisms have not yet been fully eludicated. This study was designed to in...
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Evidence for an ever-expanding variety of molecular mediators of amyloid β-protein neurotoxicity (membrane lipids, receptor proteins, channel proteins, second messengers and related signaling cascades, cytoskeletal proteins, inflammatory mediators, etc.) has led to the notion that the binding of hydrophobic Aβ assemblies to cellular membranes triggers multiple effects affecting diverse pathways...
متن کاملSelective inhibition of PCAF suppresses microglial-mediated β-amyloid neurotoxicity.
Recent studies have emphasized the functional role of the P300/CBP-associated factor (PCAF) enzyme in resistance to β-amyloid (Aβ)-mediated neurotoxicity; however, the underlying mechanisms through which PCAF regulates inflammation and neurotoxicity have not yet been elucidated. In this study, we used computer-based molecular docking simulations to perform structure-based artificial screening f...
متن کاملNeuroprotective effects of statins against amyloid β-induced neurotoxicity
A growing body of evidence suggests that disruption of the homeostasis of lipid metabolism affects the pathogenesis of Alzheimer's disease (AD). In particular, dysregulation of cholesterol homeostasis in the brain has been reported to considerably increase the risk of developing AD. Thus, dysregulation of lipid homeostasis may increase the amyloid β (Aβ) levels by affecting amyloid precursor pr...
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MMP-7, to release soluble FasL (sFasL), which deExtracellular deposits of -amyloid (A ) peptide closely creases the concentration of membrane-bound FasL match areas of neuronal loss in, and are a postmortem and has been reported to prevent apoptosis in some diagnostic indicator of, Alzheimer’s disease. Neuronal cancer cells [5]. Nagata and colleagues have shown that cultures treated with fibril...
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ژورنال
عنوان ژورنال: Nature
سال: 1993
ISSN: 0028-0836,1476-4687
DOI: 10.1038/361122a0